Metadvice Response to
COVID-19

VULNERABILITY STRATIFICATION MODEL AND INDEX FOR COVID-19 RISK


  • Current available evidence suggests a high degree of variation in the effects of the virus on individuals, and this variation will exist for therapeutic outcomes
  • Doctors will be hesitant in selecting therapies, fearing not wanting to be wrong and risk dire outcomes
  • Better set of decision rules are needed to assess individual vulnerabilities, place patients in groups based on pre-Covid health status, and stratify patients for treatment once available
  • Given the number of potential parameters of interest and the likely non-linearity of the relationship between vulnerability and these parameters, a neural network approach will give new insights for diagnostic and treatment capabilities

METADVICE IS IMPLEMENTING RISK AND TREATMENT STRATIFICATION


METADVICE IS IMPLEMENTING RISK AND TREATMENT STRATIFICATION


  • Using machine learning (ML) algorithms and a proprietary Metadvice Neural Network approach
  • Analysing real world data from existing clinical sources to refine the algorithm for patient stratification
    • Co-morbidities
    • Medication history
    • Ethnic/phenotypic factors
  • Vulnerability stratification model and index for COVID-19 risk will be deployed to:
    • Identify the risk groups using the Metadvice knowledge base
    • Enable clinicians and policy-makers to decide on the optimum approach for handling each risk group

METADVICE COVID-19 RISK AND THERAPY KNOWLEDGE BASE USP


METADVICE COVID-19 RISK AND THERAPY KNOWLEDGE BASE USP


  • Facilitate exit strategy from the current wave of infections
    • Determining risk associated with specific sub-groups of individuals not yet infected
    • Help map patient risk to de-escalating infection rates
  • Assist in prevention and impact minimisation of any future SARS-Cov-2 waves
  • Provide guidance for stratification of vaccination and treatment priorities once available
  • Extend to other similar pandemic situations

METADVICE JOINS COVID-19 HEALTHCARE COALITION


METADVICE JOINS COVID-19 HEALTHCARE COALITION


Metadvice has joined the the COVID-19 Healthcare Coalition, coordinated by MITRE and inititated by the leaders of Mayo Clinic and several Massachusetts Institute of Technology faculty leaders to accelerate the development of secure, ethical, innovative, and open source solutions to address the COVID-19 public health crisis. Metadvice will be contribting data analysis and machine learning expertise to extracting valuable insights from clincial data.

METADVICE JOINS FACULTY OF PHARMACEUTICAL MEDICINE COVID-19 EXPERT GROUP


METADVICE JOINS FACULTY OF PHARMACEUTICAL MEDICINE COVID-19 EXPERT GROUP


Metadvice will be bringing its expertise to the Faculty of Pharmaceutical Medicine COVID-19 Expert Group to help support the FPM’s latest advice and guidance during the pandemic response, and help align its objectives with ongoing FPM activities.

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