Metadvice :: Cardiovascular and Metabolic Disease | Diabetes Type 2 | Hypertension


Cardiometabolic disease is an umbrella term describing a complex and interconnected spectrum including:

Type 2 diabetes



Heart Failure

Non-alcoholic fatty liver disease (NAFLD)

Chronic kidney disease

Coronary Heart Disease

Cerebrovascular Disease

Peripheral Arterial Disease

Diagnostic and Treatment Challenges of Cardimetabolic Disease

Every patient presents a unique and complex management challenge for clinicians

Initiated or aggravated by obesity and impaired insulin action (insulin resistance)

Each disorder is also an independent risk factor for atherosclerotic cardiovascular disease - a leading cause of death worldwide

Obesity and insulin resistance also contribute to the following long-term age-related disorders, exacerbating challenges of an aging global population

Cognitive Impairment



Conditions arise from interactions between susceptibility genes, behavioural factors (nutrition, levels of physical activity), and other factors (inflammation, environmental pollution)

They have multiple shared risk factors (e.g. excess fat storage, hypertension) that make differentiation difficult, co-morbidities common, and pharmacotherapeutic risk-to-benefit considerations complex

Absolute and relative contributions of risk factors evolve over time

Medications directed to the amelioration of a specific risk factor may have positive, neutral or potentially detrimental effects on others

Metadvice Approach to Cardiometabolic Disease

cardiometabolic diseases

We view cardiometabolic disease on a spectrum of interconnected factors.

We believe in the importance of understanding contributions of this multitude of factors to the patient’s condition.

Requires an individualised approach to diagnosis and treatment over an individual’s lifespan.

cardiometabolic diseases

Cardiometabolic Syndrome

cardiometabolic syndrome by Andrew Krentz, 2017

Spectrum of care: We are building a solution to incorporate these into current best practices...

primordial prevention

averting the development of cardiometabolic risk factors)

primary prevention

avoiding first clinical cardiovascular events

secondary prevention

avoiding further vascular events

tertiary prevention

managing late-stage complications

... So that each patient can receive truly personalised care over the course of their life

mature woman using tablet

The Metadvice platform draws on national and local best practice clinical guidelines, recent clinical trial data and insights from previous clinical decisions within the Metadvice network.

Resources are integrated and presented in a user-friendly format to support clinicians in the management of patients with cardiometabolic disease.

Feedback from patients and doctors, curated data and machine learning enables identification of precise diagnostic and selection of most appropriate, personalized therapy.

Data is visualized for users to explain recommendations, letting doctors and patients draw their own evidence-based conclusions based on analysis of diagnostic and therapeutic probabilities.

See It In Action